Mahajan Niraj N, Mahajan Kshitija N, Soni Rajani N, Gaikwad Nilima L
Department of Obstetrics and Gynecology, Padhar Hospital, Padhar, Betul, Madhya Pradesh, India.
J Perinat Med. 2007;35(3):241-2. doi: 10.1515/JPM.2007.056.
Many countries have now adopted fortification, where folic acid is added to flour and intended to benefit all with rise in blood folate level. During many transformations of folate from one form to another, a proportion is accidentally converted to N(5)-methyl-THF, an inactive metabolite, the so-called "folate trap". Consideration should be given to including B(12) as well as folic acid in any program of supplementation or food fortification to prevent NTDs. This is especially applicable to developing countries like India where the majority of women are vegetarians and have borderline levels of vitamin B(12). Administration of [6S]-5-MTHF is more effective than is folic acid supplementation at improving folate status. Therefore, we urge to reconsider the "folate trap" in folic acid fortification programs.
许多国家现已采用强化措施，即在面粉中添加叶酸，旨在通过提高血液叶酸水平使所有人受益。在叶酸从一种形式向另一种形式的多次转化过程中，一部分叶酸会意外转化为无活性代谢物N(5)-甲基四氢叶酸，即所谓的“叶酸陷阱”。在任何补充或食品强化计划中，都应考虑同时纳入维生素B12和叶酸以预防神经管缺陷。这尤其适用于像印度这样的发展中国家，那里大多数女性是素食者，维生素B12水平处于临界值。服用[6S]-5-甲基四氢叶酸在改善叶酸状态方面比补充叶酸更有效。因此，我们敦促重新审视叶酸强化计划中的“叶酸陷阱”。
