什么是精神分裂症小鼠？
What is a schizophrenic mouse?
作者信息
Low Nancy C, Hardy John
机构信息
Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada.
出版信息
Neuron. 2007 May 3;54(3):348-9. doi: 10.1016/j.neuron.2007.04.014.
PMID:17481386
Abstract
In this issue of Neuron, Clapcote et al. examine mice containing missense mutations of the DISC1 gene, a locus associated with major mental illness in at least one large Scottish family. Genetic manipulation of mouse homologs of genes implicated in the etiology of psychiatric disorders is a promising avenue of research, but also one that is fraught with interpretative difficulties.
摘要
在本期《神经元》杂志中，克拉波科特等人研究了携带DISC1基因错义突变的小鼠，该基因座与至少一个苏格兰大家族中的重大精神疾病有关。对涉及精神疾病病因的基因的小鼠同源物进行基因操作是一个很有前景的研究途径，但也是一个充满解释困难的途径。
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