Age-related changes in anxiety are task-specific in the senescence-accelerated prone mouse 8.

In the senescence-accelerated prone mouse 8 (SAMP8), an excellent model of brain aging, aged individuals have impairments in learning and memory. One study has indicated that the anxiety is also reduced in those mice. However, increased anxiety with aging has been observed in other models, such as C57BL mice and rats. Altered emotion is linked to impairments in learning and memory. Thus, we were interested in further characterizing the pattern of age-related changes in anxiety in this strain. In the present study, a battery of tasks (i.e., elevated plus maze, open field, black-white alley, food neophobia and hole-board) was used to determine the age-related alterations in anxiety in the SAMP8 mice. Three age groups (2, 6, and 10 months of age) of SAMP8 mice and their control SAMR1 (senescence-accelerated resistant mouse 1) mice were used. The results showed that the effect of age was significant only in the elevated plus maze and black-white alley tasks. The SAMP8 showed a tendency toward increased anxiety with age as measured by the time spent on the open arms of elevated plus maze. When the sexes were separated for analysis, the increased anxiety was significant in the old (10-month-old) male SAMP8. In the black-white alley task, however, anxiety levels in the old male SAMP8 mice were lower than those of the middle-aged (6-month-old) mice, but similar to those in the young (2-month-old) mice. These results suggested that the age-related anxiety levels of SAMP8 mice are sex- and task-specific.