Tsudzuki M, Wakasugi N, Morioka H, Esaki K
Department of Laboratory Animal Science, College of Agriculture, University of Osaka Prefecture, Japan.
Jikken Dobutsu. 1991 Oct;40(4):529-36.
An embryonic lethal mutant was found in Japanese quail and named "stumpy limb (SL)". All SL embryos died at pre-hatching stages, showing brachycephaly, a thickened neck, short upper and lower beaks, and short and thick extremities, while their body length was similar to that of the normal embryos. Observations on the skeleton revealed a globular skull, unusual curvature of the Processus palatinus maxillaris of the upper beak, and shortening and thickening of the appendicular bones. Some embryos showed a bending of the humerus, femur and/or tibiotarsus. Abnormality was more conspicuous in the leg bones than in the wing bones. No conspicuous differences were observed in the vertebrae between the SL and normal embryos. A genetic analysis suggested that the mutation is controlled by an autosomal recessive gene, for which the gene symbol sl was proposed.
在日本鹌鹑中发现了一种胚胎致死突变体，命名为“短肢（SL）”。所有SL胚胎在孵化前阶段死亡，表现为短头畸形、颈部增厚、上下喙短、四肢短粗，而它们的体长与正常胚胎相似。对骨骼的观察发现，头骨呈球形，上喙的上颌腭突有异常弯曲，附属骨骼缩短变粗。一些胚胎的肱骨、股骨和/或胫跗骨出现弯曲。腿部骨骼的异常比翼骨更明显。SL胚胎和正常胚胎的椎骨没有明显差异。遗传分析表明，该突变由常染色体隐性基因控制，为此提出了基因符号sl。
