Funase Kozo, Tabira Takayuki, Higashi Toshio, Liang Nan, Kasai Tatsuya
Division of Health Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan.
Neurosci Lett. 2007 May 29;419(2):108-12. doi: 10.1016/j.neulet.2007.04.025. Epub 2007 Apr 19.
To explore the effect of mirror box therapy based on the mirror neuron (MN) system of the primary motor cortex (M1), we examined if direct (without a mirror) and indirect (with a mirror) observation of self-movement in healthy subjects induced changes in motor evoked potential (MEP) evoked by transcranial magnetic stimulation (TMS). MEPs were elicited from the first dorsal interosseous (FDI) and the flexor carpi radialis (FCR) muscles. Somatosensory evoked potentials (SEPs) during self-movement observation were also recorded. Both observations of self-movement with and without a mirror increased MEP amplitude. In addition, increase in MEP amplitude was specific to the prime mover muscle involved in the observed movement. The SEPs increased similar to the MEPs during both observations of self-movement with and without a mirror. We conclude that although the MN system can be activated by observing self-movement in a manner similar to that achieved by observing movement of another person, there were no detectable effect on corticospinal excitability that were specific to movements observed with a mirror.
为了基于初级运动皮层（M1）的镜像神经元（MN）系统探究镜像疗法的效果，我们检测了健康受试者直接（无镜子）和间接（有镜子）观察自身运动时，经颅磁刺激（TMS）诱发的运动诱发电位（MEP）是否发生变化。MEP由第一背侧骨间肌（FDI）和桡侧腕屈肌（FCR）引出。同时记录了自我运动观察期间的体感诱发电位（SEP）。有镜子和无镜子观察自身运动均增加了MEP波幅。此外，MEP波幅的增加特定于观察运动中涉及的原动肌。有镜子和无镜子观察自身运动期间，SEP的增加与MEP相似。我们得出结论，虽然MN系统可通过观察自身运动以类似于观察他人运动的方式被激活，但对于通过镜子观察的运动，未检测到对皮质脊髓兴奋性有特异性影响。
