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Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata.

作者信息

Hwu Yuh-Ming, Li Sheng-Hsiang, Lee Robert Kuo-kuang, Tsai Yu-Hui, Yeh Tien-Shun, Lin Shyr-Yeu

机构信息

Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.

出版信息

Fertil Steril. 2008 Feb;89(2):468-71. doi: 10.1016/j.fertnstert.2007.02.031. Epub 2007 May 4.

DOI:10.1016/j.fertnstert.2007.02.031
PMID:17482170
Abstract

This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor alpha (PDGFR-alpha), and receptor beta (PDGFR-beta) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-alpha, or PDGFR-beta between leiomyomata and the adjacent myometrial tissues.

摘要

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