Pettitt D J, Bennett P H, Saad M F, Charles M A, Nelson R G, Knowler W C
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85014.
Diabetes. 1991 Dec;40 Suppl 2:126-30. doi: 10.2337/diab.40.2.s126.
The long-term effects on offspring of abnormal glucose tolerance detected during pregnancy were examined in 552 Pima Indian offspring 5-24 yr of age. Fasting hyperinsulinemia, presumably reflecting increased insulin resistance, occurred at an earlier age in the offspring of women who had abnormal glucose tolerance during pregnancy, and these offspring were more obese and had higher rates of abnormal glucose tolerance. When confounding factors were controlled, a 1 mM higher 2-h postload glucose concentration during pregnancy resulted in a significantly higher prevalence of diabetes in the offspring (odds ratio = 162). Maternal 2-h glucose concentration during pregnancy was also a significant predictor of glucose concentration during pregnancy in the offspring (P = 0.011). Thus, the metabolic abnormalities associated with the diabetic pregnancy result in long-term effects on the offspring, including insulin resistance, obesity, and diabetes, which in turn may contribute to transmission of risk for developing the same problems in the next generation.
对552名年龄在5至24岁的皮马印第安人后代进行了研究，以检测孕期发现的糖耐量异常对后代的长期影响。空腹高胰岛素血症，可能反映胰岛素抵抗增加，在孕期糖耐量异常女性的后代中出现得更早，而且这些后代更肥胖，糖耐量异常发生率更高。当混杂因素得到控制时，孕期2小时负荷后血糖浓度每升高1 mM，后代患糖尿病的患病率就显著更高（优势比 = 162）。孕期母亲的2小时血糖浓度也是后代孕期血糖浓度的一个重要预测指标（P = 0.011）。因此，与糖尿病妊娠相关的代谢异常会对后代产生长期影响，包括胰岛素抵抗、肥胖和糖尿病，这反过来可能会导致下一代出现同样问题的风险传递。
