Pettitt D J, Nelson R G, Saad M F, Bennett P H, Knowler W C
Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes, Digestive, and Kidney Diseases, Phoenix, AZ 85016.
Diabetes Care. 1993 Jan;16(1):310-4. doi: 10.2337/diacare.16.1.310.
To review the long-term effects of the diabetic pregnancy on the offspring among the Pima Indians of Arizona.
Studies published by the Phoenix Epidemiology and Clinical Research branch of the National Institute of Diabetes and Digestive and Kidney Diseases, since the inception of the longitudinal diabetes studies in 1965 were reviewed. In addition, pertinent studies from other centers, mentioned as references in these publications, were reviewed. As far as possible, all original articles and abstracts on this aspect of the Pima Indian studies were discussed.
The offspring of women who had diabetes during pregnancy, on average, were more obese and had higher glucose concentrations and more diabetes than the offspring of women who developed diabetes after pregnancy or who remained nondiabetic. Although no new analyses were attempted, several of the older publications were updated by repeating the analyses on later, expanded data sets.
The diabetic pregnancy, in addition to its effects on the newborn, has effects on the subsequent growth and glucose metabolism of the offspring. These effects are in addition to genetically determined traits.
回顾糖尿病妊娠对亚利桑那州皮马印第安人后代的长期影响。
对美国国立糖尿病、消化和肾脏疾病研究所凤凰城流行病学与临床研究分部自1965年开展纵向糖尿病研究以来发表的研究进行了回顾。此外，还回顾了这些出版物中作为参考文献提及的其他中心的相关研究。尽可能讨论了皮马印第安人研究这方面的所有原始文章和摘要。
孕期患糖尿病的女性的后代，平均而言，比孕期后患糖尿病或一直未患糖尿病的女性的后代更肥胖，血糖浓度更高，患糖尿病的几率也更高。虽然未尝试进行新的分析，但通过对后来扩大的数据集重复分析，更新了一些较早的出版物。
糖尿病妊娠除了对新生儿有影响外，还会对后代的后续生长和葡萄糖代谢产生影响。这些影响是除了基因决定的特征之外的。
