Peters Jan, Wilson David P, Myers Garry, Timms Peter, Bavoil Patrik M
Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA.
Trends Microbiol. 2007 Jun;15(6):241-51. doi: 10.1016/j.tim.2007.04.005. Epub 2007 May 7.
Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-dependent, T3S-mediated chlamydial growth and late differentiation, suggest that chlamydiae contained in small non-fusogenic inclusions will persist. Here, we further discuss the model in the context of in vitro-persistent, stress-induced aberrantly enlarged forms and of recent studies using small molecule inhibitors of T3S. A general mechanism is emerging whereby both early- and mid-cycle T3S-mediated activities and late T3S inactivation upon detachment of chlamydiae from the inclusion membrane are crucial for chlamydial intracellular development.
III型分泌（T3S）是一种对衣原体科以及许多其他病原体的生物学特性至关重要的机制，这些病原体的毒力取决于有毒效应蛋白向被感染真核细胞内的胞质靶点的转运。使用先前描述的接触依赖性、T3S介导的衣原体生长和晚期分化模型进行的生物数学模拟表明，包含在小的非融合性包涵体内的衣原体将持续存在。在这里，我们将在体外持续存在、应激诱导的异常扩大形式以及使用T3S小分子抑制剂的最新研究背景下进一步讨论该模型。一种普遍的机制正在显现，即早期和中期T3S介导的活动以及衣原体从包涵体膜脱离时T3S的晚期失活对于衣原体的细胞内发育至关重要。
