通过RecQ解旋酶在斑马鱼胚胎中操纵有丝分裂重组。
Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases.
作者信息
Xie Jing, Bessling Seneca L, Cooper Timothy K, Dietz Harry C, McCallion Andrew S, Fisher Shannon
机构信息
The McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
Genetics. 2007 Jun;176(2):1339-42. doi: 10.1534/genetics.107.072983. Epub 2007 May 4.
Abstract
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.
摘要
RecQ DNA解旋酶可解决Rad-51介导的重组并抑制异常同源重组。RecQ基因缺失与癌症易感性和有丝分裂重组增加有关。我们基于斑马鱼色素突变体开发了一种体内检测方法来抑制RecQ活性，并证明斑马鱼RecQ基因在抑制有丝分裂重组方面具有保守功能。
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