Stein M, Kuten A, Ben-Arieh Y, Cohen Y, Haim N
Northern Israel Oncology Center, Haifa.
Harefuah. 1991 Jul;121(1-2):4-8.
Between 1973 and 1989, 739 patients with non-Hodgkin's lymphoma were referred here for treatment, of whom 10 (1.4%) had primary brain lymphoma (PBL) and 1 had acquired immunodeficiency syndrome (AIDS). There were 7 females and 3 males (mean age 58 years, range 35-77). Duration of symptoms ranged from several days to 3 weeks. The presenting symptoms were secondary to increased intracranial pressure. Computerized tomography (CT) performed in 8 revealed a solitary lesion in 7. Other CT scan features were various degrees of contrast enhancement, edema and midline shift. The most common site was the frontal lobe; infratentorially, the cerebellum was the most frequent site. The diagnosis was established in 8 patients by surgery and in 2 at autopsy. The most common subtype was the diffuse, large cell, immunoblastic lymphoma. 5 patients were irradiated following subtotal excision and 2 had combined radiation therapy and high-dose methotrexate-based chemotherapy; only 1 had no postoperative treatment. All patients treated by radiotherapy alone died within 3-5 months after diagnosis. The 2 who received combined therapy are alive, 15 and 48 months after diagnosis, respectively.
1973年至1989年间，739例非霍奇金淋巴瘤患者被转诊至此接受治疗，其中10例（1.4%）患有原发性脑淋巴瘤（PBL），1例患有获得性免疫缺陷综合征（AIDS）。患者中有7名女性和3名男性（平均年龄58岁，范围35 - 77岁）。症状持续时间从数天到3周不等。主要症状是由颅内压升高引起的。8例患者进行了计算机断层扫描（CT），其中7例显示为单个病灶。其他CT扫描特征包括不同程度的对比增强、水肿和中线移位。最常见的部位是额叶；幕下则以小脑最为常见。8例患者通过手术确诊，2例通过尸检确诊。最常见的亚型是弥漫性大细胞免疫母细胞淋巴瘤。5例患者在次全切除后接受了放疗，2例接受了放疗联合以大剂量甲氨蝶呤为基础的化疗；只有1例未接受术后治疗。所有仅接受放疗的患者在诊断后3 - 5个月内死亡。接受联合治疗的2例患者分别在诊断后15个月和48个月时仍存活。
