一种通过趋化因子CC趋化因子配体4介导抑制作用的人类CD8 +调节性T细胞亚群的鉴定。
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.
作者信息
Joosten Simone A, van Meijgaarden Krista E, Savage Nigel D L, de Boer Tjitske, Triebel Frédéric, van der Wal Annemieke, de Heer Emile, Klein Michèl R, Geluk Annemieke, Ottenhoff Tom H M
机构信息
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
出版信息
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8029-34. doi: 10.1073/pnas.0702257104. Epub 2007 May 2.
Abstract
Regulatory T cells (Treg) comprise multiple subsets and are important in controlling immunity and inflammation. However, the induction and mode of action of the various distinct Treg subsets remain ill defined, particularly in humans. Here, we describe a human CD8+ lymphocyte activation gene-3 (LAG-3)+CD25+FoxP3+ Treg subset, which suppresses T cells partly through the secretion of CC chemokine ligand 4 (CCL4), which can inhibit T cell activation by interfering with T cell receptor signaling. CD8+ Tregs are expanded by antigen in in vivo-primed donors, and can be detected in pathogen-infected human tissue. This CD8+LAG-3+CD25+FoxP3+CCL4+ Treg subset thus may play a role in immunoregulation in humans, including infectious diseases.
摘要
调节性T细胞（Treg）包含多个亚群，在控制免疫和炎症方面发挥着重要作用。然而，各种不同的Treg亚群的诱导和作用模式仍不明确，尤其是在人类中。在此，我们描述了一种人类CD8 +淋巴细胞激活基因3（LAG - 3）+ CD25 + FoxP3 + Treg亚群，它部分通过分泌CC趋化因子配体4（CCL4）来抑制T细胞，CCL4可通过干扰T细胞受体信号传导来抑制T细胞激活。CD8 + Tregs在体内致敏的供体中可被抗原扩增，并可在病原体感染的人体组织中检测到。因此，这种CD8 + LAG - 3 + CD25 + FoxP3 + CCL4 + Treg亚群可能在人类免疫调节中发挥作用，包括在传染病中。
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