Reitz Christiane, Brickman Adam M, Luchsinger José A, Wu William E, Small Scott A, Tang Ming-Xin
Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.
Am J Geriatr Cardiol. 2007 May-Jun;16(3):183-8. doi: 10.1111/j.1076-7460.2007.06511.x.
The authors compared the frequency of structural and functional heart abnormalities assessed using transthoracic echocardiography among persons with Alzheimer's disease, vascular dementia, stroke, and healthy control subjects. Compared with controls, patients with Alzheimer's disease were more likely to have aortic valve thickening, aortic valve regurgitation, left ventricular wall motion abnormalities, left ventricular hypertrophy, and reduced ejection fraction. Persons with vascular dementia were more likely to have aortic valve regurgitation, but mitral valve thickening and tricuspid valve regurgitation were also more frequent. In the absence of dementia, persons with stroke differed from controls by more frequent mitral valve calcifications. With the increasing prevalence of Alzheimer's disease and vascular dementia, clinicians have to be more attentive to the presence of structural heart disease and its complications in persons with these conditions.
作者比较了使用经胸超声心动图评估的阿尔茨海默病、血管性痴呆、中风患者及健康对照者心脏结构和功能异常的频率。与对照组相比，阿尔茨海默病患者更易出现主动脉瓣增厚、主动脉瓣反流、左心室壁运动异常、左心室肥厚及射血分数降低。血管性痴呆患者更易出现主动脉瓣反流，二尖瓣增厚和三尖瓣反流也更常见。在无痴呆的情况下，中风患者与对照组相比，二尖瓣钙化更常见。随着阿尔茨海默病和血管性痴呆患病率的上升，临床医生必须更加关注这些疾病患者中心脏结构疾病及其并发症的存在情况。
