未检出的老年阿尔茨海默病和其他痴呆症患者外周动脉疾病。
Undetected Peripheral Arterial Disease Among Older Adults With Alzheimer's Disease and Other Dementias.
机构信息
1 Department of Internal Medicine, Gulhane Medical School, Health Sciences University, Ankara, Turkey.
2 Internal Medicine Clinic, Gulhane Teaching and Research Hospital, Turkish Ministry of Health, Ankara, Turkey.
出版信息
Am J Alzheimers Dis Other Demen. 2018 Feb;33(1):5-11. doi: 10.1177/1533317517724000. Epub 2017 Aug 8.
BACKGROUND
Peripheral arterial disease (PAD) was reported to increase the risk of dementia(s) even more than stroke. We assessed the prevalence of PAD in a group with definite diagnosis of dementia.
METHODS
Patients aged 65 years or older with Alzheimer's disease (AD), vascular dementia (VaD), or AD-VaD were enrolled (n = 162, mean age: 78.87 [6.05] years). An age- and gender-matched control group was also included (n = 190). Peripheral arterial disease was diagnosed by the ankle-brachial index.
RESULTS
Frequency of PAD among patients with and without dementia was 35.2% and 16.3%, respectively ( P < .001), being similar among different types of dementia. After adjustment for covariates, dementia (odds ratio: 2.41, 95% confidence interval: 1.34-4.32; P = .003) was among the predictors of PAD diagnosis along with older age, female gender, and diabetes.
CONCLUSIONS
The prevalence of PAD was more than double in patients with dementia, with no difference among AD, VaD, and AD-VaD types.
背景
外周动脉疾病（PAD）比中风更能增加痴呆的风险。我们评估了一组明确诊断为痴呆的患者中 PAD 的患病率。
方法
纳入年龄在 65 岁或以上的阿尔茨海默病（AD）、血管性痴呆（VaD）或 AD-VaD 患者（n=162，平均年龄：78.87[6.05]岁）。还纳入了年龄和性别匹配的对照组（n=190）。PAD 通过踝肱指数诊断。
结果
痴呆患者和无痴呆患者中 PAD 的发生率分别为 35.2%和 16.3%（P<.001），不同类型的痴呆发生率相似。调整协变量后，痴呆（比值比：2.41，95%置信区间：1.34-4.32；P=0.003）与年龄较大、女性和糖尿病一样，是 PAD 诊断的预测因素之一。
结论
痴呆患者的 PAD 患病率是无痴呆患者的两倍多，AD、VaD 和 AD-VaD 类型之间没有差异。
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