Riaux A, Bourrat E, Pinquier L, Morel P, Dubertret L, Petit A
Service de Dermatologie 1, Hôpital Saint Louis, Paris.
Ann Dermatol Venereol. 2007 Apr;134(4 Pt 1):327-31. doi: 10.1016/s0151-9638(07)89185-x.
Confluent and reticulate papillomatosis of Gougerot and Carteaud is a rare entity and a subject of controversy in terms of nosology. It has occasionally been regarded as a peculiar variant of acanthosis nigricans, pityriasis versicolor or amyloidosis.
To discuss confluent and reticulate papillomatosis and its diagnostic criteria as a distinct entity.
Retrospective study from 1994 to 2005 based on photographic files from 2 dermatology wards at the Saint Louis Hospital, Paris. Files containing a precise clinical description of the rash and at least one mycological element were included.
Nine cases were included (6 females, 3 males). These patients showed clinical features comprising elementary lesion, distribution and topography corresponding to the classical description; histology was also consistent with confluent and reticulate papillomatosis, with no signs of amylosis and negative fungal samples or failure of antifungal treatment. One patient was presenting associated acanthosis nigricans. Doxycycline was efficacious in 4 cases in which it was evaluated.
Confluent and reticulate papillomatosis is a definite entity and is not a superficial fungal disease. It must be distinguished from pityriasis versicolor as well as acanthosis nigricans and cutaneous amyloidosis. The therapeutic efficacy of oral cyclines (doxycycline or minocycline) appears to be an important distinguishing feature that can serve as a diagnostic criterion.
Gougerot和Carteaud的融合性网状乳头瘤病是一种罕见疾病，在疾病分类学方面存在争议。它偶尔被视为黑棘皮病、花斑糠疹或淀粉样变性的一种特殊变体。
讨论融合性网状乳头瘤病及其作为一种独特疾病的诊断标准。
基于巴黎圣路易医院2个皮肤科病房1994年至2005年的照片档案进行回顾性研究。纳入包含皮疹精确临床描述和至少一项真菌学检查结果的档案。
纳入9例（6例女性，3例男性）。这些患者的临床特征包括基本损害、分布和部位，与经典描述相符；组织学也与融合性网状乳头瘤病一致，无淀粉样变性迹象，真菌样本阴性或抗真菌治疗无效。1例患者伴有黑棘皮病。4例接受评估的患者使用强力霉素有效。
融合性网状乳头瘤病是一种明确的疾病，不是浅表真菌病。它必须与花斑糠疹、黑棘皮病和皮肤淀粉样变性相鉴别。口服四环素（强力霉素或米诺环素）的治疗效果似乎是一个重要的鉴别特征，可作为诊断标准。
