Bajpai A K, Bhanu Smitha
Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, MP 482001, India.
J Mater Sci Mater Med. 2007 Aug;18(8):1613-21. doi: 10.1007/s10856-007-3020-y. Epub 2007 May 5.
The microspheres of crosslinked starch have been prepared and characterized by IR spectral analysis and SEM technique. The prepared microspheres were loaded with an anticoagulant drug 'heparin' and the kinetics of in-vitro release of heparin was investigated spectrophotometrically at physiological pH (7.4) and body temperature (37 degrees C). The influence of percent loading of heparin, chemical architecture of the microspheres and pH of the release medium were examined on the release profiles of the drug. The chemical stability of heparin was tested in phosphate buffer saline (pH 7.4) and the release was also studied in various simulated biological fluids.
已制备交联淀粉微球，并通过红外光谱分析和扫描电子显微镜技术对其进行了表征。将制备的微球负载抗凝血药物“肝素”，并在生理pH值（7.4）和体温（37摄氏度）下采用分光光度法研究肝素的体外释放动力学。考察了肝素负载百分比、微球化学结构和释放介质pH值对药物释放曲线的影响。在磷酸盐缓冲盐水（pH 7.4）中测试了肝素的化学稳定性，并在各种模拟生物流体中研究了其释放情况。
