Chiu Brian C-H, Soni Lori, Gapstur Susan M, Fought Angela J, Evens Andrew M, Weisenburger Dennis D
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611-4402, USA.
Cancer Causes Control. 2007 Aug;18(6):677-85. doi: 10.1007/s10552-007-9013-9. Epub 2007 May 7.
Few studies have explored the potential association between body mass index (BMI) and non-Hodgkin lymphoma (NHL) according to histologic subtypes, or have evaluated BMI at different periods in the subject's life, and the results of these studies have been inconsistent.
A population-based, case-control study of 387 patients with NHL and 535 controls conducted in Nebraska between 1999 and 2002.
Information on usual adult weight, weight at the ages 20-29, 40-49, and 60-69 years, height, physical activity, and other lifestyle factors was collected by telephone interview. A self-administered semi-quantitative food frequency questionnaire was used to collect dietary intake. Risk was estimated by odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, total energy intake, physical activity, and other confounding factors.
Higher adult BMI was associated with risk of NHL (OR=1.4; 95% CI=0.9-2.0) comparing the obese group (BMI >or= 30.0 kg/m(2)) with the normal weight group (BMI=18.5-24.9 kg/m(2)). The risk was higher for those who were class 2 obese (BMI >or= 35.0 kg/m(2), OR=1.7; 95% CI=1.0-2.9). The positive association was similar among men and women. An excess risk of NHL was associated with high BMI at ages 40-49 years (OR=1.6; 95% CI=1.0-2.5), and to a lesser extent, at ages 20-29 years (OR=1.4; 95% CI=0.8-2.5). Obesity at ages 40-49 years was also associated with a higher risk of small lymphocytic lymphoma (OR=4.5; 95% CI=1.5-13.3), diffuse large B-cell NHL (OR=1.8; 95% CI=0.9-3.9) and follicular NHL (OR=1.8; 95% CI=0.9-3.5).
Obesity is associated with risk of NHL overall. Obesity at ages 40-49 years is also associated with a higher risk of NHL overall, and particularly small lymphocytic, follicular, and diffuse large B-cell NHL.
很少有研究根据组织学亚型探讨体重指数（BMI）与非霍奇金淋巴瘤（NHL）之间的潜在关联，或者评估个体生命中不同时期的BMI，而且这些研究结果并不一致。
1999年至2002年在 Nebraska 进行的一项基于人群的病例对照研究，纳入387例NHL患者和535例对照。
通过电话访谈收集有关成年时的通常体重、20 - 29岁、40 - 49岁和60 - 69岁时的体重、身高、身体活动及其他生活方式因素的信息。使用一份自行填写的半定量食物频率问卷收集饮食摄入量。通过比值比（OR）和95%置信区间（CI）估计风险，并对年龄、总能量摄入、身体活动及其他混杂因素进行校正。
将肥胖组（BMI≥30.0 kg/m²）与正常体重组（BMI = 18.5 - 24.9 kg/m²）相比，较高的成年BMI与NHL风险相关（OR = 1.4；95% CI = 0.9 - 2.0）。2级肥胖者（BMI≥35.0 kg/m²，OR = 1.7；95% CI = 1.0 - 2.9）风险更高。男女之间的正相关相似。40 - 49岁时高BMI与NHL额外风险相关（OR = 1.6；95% CI = 1.0 - 2.5），20 - 29岁时相关性较小（OR = 1.4；95% CI = 0.8 - 2.5）。40 - 49岁时肥胖也与小淋巴细胞淋巴瘤（OR = 4.5；95% CI = 1.5 - 13.3）、弥漫性大B细胞NHL（OR = 1.8；95% CI = 0.9 - 3.9）和滤泡性NHL（OR = 1.8；95% CI = 0.9 - 3.5）的较高风险相关。
肥胖总体上与NHL风险相关。40 - 49岁时肥胖也与NHL总体较高风险相关，尤其是小淋巴细胞、滤泡性和弥漫性大B细胞NHL。
