1Division of Biostatistics and Epidemiology,Cincinnati Children's Hospital Medical Center,Cincinnati,OH,USA.
2Department of Health Studies,University of Chicago,5841 South Maryland Avenue,MC 2007,Chicago,IL 60637,USA.
Public Health Nutr. 2014 Jul;17(7):1531-7. doi: 10.1017/S1368980013001249. Epub 2013 May 9.
Previous studies examining the role of single foods or nutrients in the aetiology of non-Hodgkin lymphoma (NHL) have produced inconsistent findings. Few studies have examined associations for dietary patterns, which may more accurately reflect patterns of consumption and the complexity of dietary intake. The objective of the present study was to examine whether dietary patterns identified by factor analysis were associated with NHL risk.
Case-control.
Population-based sample residing in Nebraska from 1999 to 2002.
A total of 336 cases and 460 controls.
Factor analysis identified two major dietary patterns: (i) a 'Meat, Fat and Sweets' dietary pattern characterized by high intakes of French fries, red meat, processed meat, pizza, salty snacks, sweets and desserts, and sweetened beverages; and (ii) a 'Fruit, Vegetables and Starch' dietary pattern characterized by high intakes of vegetables, fruit, fish, and cereals and starches. In multivariable logistic regression models, the 'Meat, Fat and Sweets' dietary pattern was associated with an increased risk of overall NHL (ORQ4 v. Q1 = 3·6, 95 % CI 1·9, 6·8; P trend = 0·0004), follicular lymphoma (ORQ4 v. Q1 = 3·1, 95 % CI 1·2, 8·0; P trend = 0·01), diffuse large B-cell lymphoma (ORQ4 v. Q1 = 3·2, 95 % CI 1·1, 9·0; P trend = 0·09) and marginal zone lymphoma (ORQ4 v. Q1 = 8·2, 95 % CI 1·3, 51·2; P trend = 0·05). No association with overall or subtype-specific risk was detected for the 'Fruit, Vegetables and Starch' dietary pattern. No evidence of heterogeneity was detected across strata of age, sex, BMI, smoking status or alcohol consumption.
Our results suggest that a dietary pattern high in meats, fats and sweets may be associated with an increased risk of NHL.
之前研究单一食物或营养素在非霍奇金淋巴瘤（NHL）发病机制中的作用，结果不一致。很少有研究检测饮食模式的相关性，而饮食模式可能更准确地反映消耗模式和饮食摄入的复杂性。本研究旨在探讨通过因子分析确定的饮食模式是否与 NHL 风险相关。
病例对照。
1999 年至 2002 年期间居住在内布拉斯加州的人群为基础的样本。
共 336 例病例和 460 例对照。
因子分析确定了两种主要的饮食模式：（i）“肉、脂肪和甜食”饮食模式，其特点是大量摄入薯条、红肉、加工肉、比萨饼、咸零食、甜食和甜点以及加糖饮料；（ii）“水果、蔬菜和淀粉”饮食模式，其特点是大量摄入蔬菜、水果、鱼和谷物和淀粉。在多变量逻辑回归模型中，“肉、脂肪和甜食”饮食模式与 NHL 总风险增加相关（ORQ4 v. Q1=3.6，95%CI1.9，6.8；P 趋势=0.0004），滤泡性淋巴瘤（ORQ4 v. Q1=3.1，95%CI1.2，8.0；P 趋势=0.01），弥漫性大 B 细胞淋巴瘤（ORQ4 v. Q1=3.2，95%CI1.1，9.0；P 趋势=0.09）和边缘区淋巴瘤（ORQ4 v. Q1=8.2，95%CI1.3，51.2；P 趋势=0.05）。“水果、蔬菜和淀粉”饮食模式与 NHL 总发病率或亚型特异性风险无关联。未发现年龄、性别、BMI、吸烟状况或饮酒量分层的异质性证据。
我们的研究结果表明，富含肉类、脂肪和甜食的饮食模式可能与 NHL 风险增加相关。
