Shandilya Jayasha, Gadad Shrikanth, Swaminathan V, Kundu Tapas K
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P O, Bangalore 560064, India.
Subcell Biochem. 2007;41:111-24. doi: 10.1007/1-4020-5466-1_6.
Histone chaperones are the histone interacting factors that stimulate histone transfer reaction without being a part of the final product. They are involved in the histone storage, histone translocation to the nucleus, and histone exchange and histone deposition onto the DNA for replication dependent chromatin assembly. Interestingly, they have also been demonstrated to possess the histone removal activity. While the involvement of the histone chaperones in chromatin transcription is undisputed, the question of their local versus global involvement is under scrutiny. This review enumerates the role played by various histone chaperones in the establishment of chromatin structure and regulation of chromatin transcription. The role of histone chaperones in disease manifestation is not very clear, preliminary results with few histone chaperones suggest that expression and function of these factors dramatically alters in carcinogenesis. This review will also focus on the possible role of histone chaperones in cancer diagnosis and progression
组蛋白伴侣是与组蛋白相互作用的因子，它们能刺激组蛋白转移反应，而本身并非最终产物的一部分。它们参与组蛋白的储存、组蛋白向细胞核的转运、组蛋白交换以及在依赖复制的染色质组装过程中组蛋白在DNA上的沉积。有趣的是，它们还被证明具有组蛋白移除活性。虽然组蛋白伴侣参与染色质转录这一点毫无争议，但它们是局部参与还是全局参与的问题仍在研究之中。本综述列举了各种组蛋白伴侣在染色质结构建立和染色质转录调控中所起的作用。组蛋白伴侣在疾病表现中的作用尚不清楚，少数组蛋白伴侣的初步结果表明，这些因子的表达和功能在致癌过程中会发生显著改变。本综述还将聚焦于组蛋白伴侣在癌症诊断和进展中可能发挥的作用。
