Saini D, Biris A S, Srirama P K, Mazumder M K
Department of Molecular Microbiology and Immunology, Health Sciences Center, Saint Louis University, St. Louis, MO, USA.
Pharm Dev Technol. 2007;12(1):35-41. doi: 10.1080/10837450601166536.
Aerosol particles generated by inhalers for respiratory drug delivery acquire electrostatic charge during the dispersion process. The electrostatic charge distribution of the particles can affect the efficiency of drug delivery by influencing both the transport and deposition of inhaled particles in the human lung. To analyze the electrostatic charge acquired by the aerosol particles, two sets of metered-dose inhaler (MDI) and dry powder inhaler (DPI) devices were investigated. Both the particle size and charge distributions were measured simultaneously by using an electrical single-particle aerodynamic relaxation time (E-SPART) analyzer. The analyzer was calibrated with particles of known size, which were generated by a vibrating orifice aerosol generator (TSI Inc.) and charge using the Faraday cup method. The charge distributions of the pharmaceutical aerosols from both the DPI and MDI devices were bipolar in nature. Although the net charge-to-mass ratio was less than 0.2 microC/g, the individual particles were charged with a relatively high charge: -2 to + 2 microC/g. The count mean aerodynamic diameter of the aerosols generated from these devices was 3-5 microm.
用于呼吸道给药的吸入器产生的气溶胶颗粒在分散过程中会获得静电荷。颗粒的静电荷分布会通过影响吸入颗粒在人肺中的传输和沉积来影响药物递送效率。为了分析气溶胶颗粒获得的静电荷，研究了两组定量吸入器（MDI）和干粉吸入器（DPI）装置。通过使用电单颗粒空气动力学弛豫时间（E-SPART）分析仪同时测量颗粒大小和电荷分布。分析仪用已知大小的颗粒进行校准，这些颗粒由振动孔口气溶胶发生器（TSI公司）产生，并使用法拉第杯法充电。来自DPI和MDI装置的药物气溶胶的电荷分布本质上是双极的。尽管净电荷与质量之比小于0.2微库仑/克，但单个颗粒带有相对较高的电荷：-2至+2微库仑/克。由这些装置产生的气溶胶的计数平均空气动力学直径为3-5微米。
