Motarjeme Amir
Midwest Vascular Institute of Illinois, Downers Grove, Illinois 60515, USA.
J Endovasc Ther. 2007 Apr;14(2):251-6. doi: 10.1177/152660280701400218.
To report a single-center clinical experience with ultrasound-enhanced thrombolysis in the treatment of both arterial and venous thromboses.
From January 2005 to June 2006, 33 patients (23 men; age range 39-90 years) with 36 occlusions were treated using ultrasound-enhanced thrombolytic therapy for acute and chronic arterial and venous occlusions. After diagnostic angiography, the occlusions were crossed with an appropriately sized Lysus infusion catheter for infusion of urokinase (80,000-120,000 IU/h).
Technical success and complete lysis was achieved in 96% of the arterial and 83% of the venous occlusions. Two patients with chronic occlusions (one superficial femoral artery and one iliac vein) were refractory to lytic therapy. Average time for complete lysis was 16.4 hours (range 3-25) for arterial occlusions and 21.2 hours (range 6-43) in patients with deep vein thrombosis.
Successful clot lysis can be achieved with a high rate of success in a shorter time than conventional thrombolysis using ultrasound-enhanced thrombolysis in both acute and chronic arterial and venous thromboses.
报告单中心应用超声强化溶栓治疗动静脉血栓形成的临床经验。
2005年1月至2006年6月，33例患者（23例男性；年龄39 - 90岁）共36处血管闭塞，采用超声强化溶栓疗法治疗急性和慢性动静脉闭塞。诊断性血管造影后，用尺寸合适的Lysus输注导管穿过闭塞部位，输注尿激酶（80,000 - 120,000 IU/h）。
96%的动脉闭塞和83%的静脉闭塞实现了技术成功及完全溶解。2例慢性闭塞患者（1例股浅动脉和1例髂静脉）对溶栓治疗无效。动脉闭塞完全溶解的平均时间为16.4小时（范围3 - 25小时），深静脉血栓形成患者为21.2小时（范围6 - 43小时）。
在急性和慢性动静脉血栓形成中，与传统溶栓相比，应用超声强化溶栓能在更短时间内高成功率地实现血栓溶解。
