Kushwah Rahul, Cao Huibi, Hu Jim
Physiology and Experimental Medicine Programme, the Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G1X8.
Cell Mol Immunol. 2007 Apr;4(2):81-9.
Innate immune responses form the first line of defense against foreign insults and recently significant advances have been made in our understanding of the initiation of innate immune response along with its ability to modulate inflammation. In airway diseases such as asthma, COPD and cystic fibrosis, over reacting of the airway innate immune responses leads to cytokine imbalance and airway remodeling or damage. Helper-dependent adenoviral vectors have the potential to deliver genes to modulate airway innate immune responses and have many advantages over its predecessors. However, there still are a few limitations that need to be addressed prior to their use in clinical applications.
固有免疫反应构成了抵御外来侵害的第一道防线，最近我们对固有免疫反应的启动及其调节炎症的能力的理解取得了重大进展。在哮喘、慢性阻塞性肺疾病和囊性纤维化等气道疾病中，气道固有免疫反应过度会导致细胞因子失衡以及气道重塑或损伤。辅助依赖型腺病毒载体有潜力递送基因来调节气道固有免疫反应，并且相较于其前身有许多优势。然而，在将它们用于临床应用之前，仍有一些局限性需要解决。
