Kolb Martin, Martin Gail, Medina Maria, Ask Kjetil, Gauldie Jack
Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5.
Chest. 2006 Sep;130(3):879-84. doi: 10.1378/chest.130.3.879.
Gene therapy has not yet met the high expectations of "the early days." However, it is a promising new treatment for lung diseases. Not only single gene disorders such as CF are potential candidates for gene therapy, but also cancer and chronic lung diseases characterized by an imbalance of damaging and protective mechanisms. This review summarizes the recent advances in the development of more efficient gene transfer systems and highlights areas of clinical application of gene therapy.
基因治疗尚未达到“早期”的高度期望。然而，它是一种治疗肺部疾病的有前景的新方法。不仅像囊性纤维化这样的单基因疾病是基因治疗的潜在候选对象，而且以损伤和保护机制失衡为特征的癌症和慢性肺部疾病也是如此。这篇综述总结了更高效基因传递系统开发的最新进展，并突出了基因治疗的临床应用领域。
