Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA.
Crit Care Clin. 2011 Jul;27(3):705-18. doi: 10.1016/j.ccc.2011.04.002.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by acute respiratory failure and are associated with diverse disorders. Gene therapy is a potentially powerful approach to treat diseases related to ALI/ARDS, and numerous viral and nonviral methods for gene delivery to the lung have been developed. Discussed are recent advances in the development of more efficient viral and nonviral gene transfer systems, and the current status of gene therapy applied to ALI/ARDS-associated pulmonary diseases is reviewed. With the development of more efficient gene therapy vectors, gene therapy is a promising strategy for clinical application.
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）的特征是急性呼吸衰竭，并与多种疾病有关。基因治疗是治疗与 ALI/ARDS 相关疾病的一种潜在强大方法，已经开发出许多用于将基因递送到肺部的病毒和非病毒方法。本文讨论了开发更有效的病毒和非病毒基因转移系统的最新进展，并综述了基因治疗在与 ALI/ARDS 相关的肺部疾病中的应用现状。随着更有效的基因治疗载体的发展，基因治疗是一种很有前途的临床应用策略。
