Bukh Jens O Drachmann, Bock Camilla, Mors Niels Peter Ole, Kessing Lars Vedel
Rigshospitalet, Psykiatrisk Klinik, Forskningsenheden, København Ø.
Ugeskr Laeger. 2007 Apr 16;169(16):1439-41.
The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. The results are still preliminary but suggest that treatment response to antidepressant drugs is influenced by genetic factors. They also indicate that the genetic component is polygenic and highly complex and might manifest itself in interaction with other biological and environmental factors.
心理药理学治疗的结果可能取决于各种神经递质系统的基因多态性。我们总结了与血清素系统相关的基因变异和对选择性血清素再摄取抑制剂反应之间关联的研究。结果仍然是初步的，但表明抗抑郁药物的治疗反应受遗传因素影响。它们还表明遗传成分是多基因且高度复杂的，可能在与其他生物和环境因素的相互作用中表现出来。
