Lu Chuan-Zhen, Xiao Bao-Guo
Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Front Biosci. 2007 May 1;12:2869-75. doi: 10.2741/2278.
In several experimental studies of cerebral ischemia, G-CSF exerts neuroprotective effects through different mechanisms, including mobilization of hematopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti-inflammation. Hence, G-CSF not only inhibits neuron death, but also generates "new" neural tissue formation. A small pilot trial reports on the safety and feasibility of G-CSF therapy in stroke patients. According to this evidence, we can speculate that G-CSF, being used either alone or in combination with another agent, should be an effective strategy in the treatment of cerebral ischemia.
在几项脑缺血的实验研究中，粒细胞集落刺激因子（G-CSF）通过不同机制发挥神经保护作用，包括动员造血干细胞、抗凋亡、神经元分化、血管生成和抗炎作用。因此，G-CSF不仅能抑制神经元死亡，还能促使“新”神经组织形成。一项小型试点试验报告了G-CSF治疗中风患者的安全性和可行性。根据这些证据，我们可以推测，单独使用或与其他药物联合使用G-CSF应该是治疗脑缺血的有效策略。
