Xing Yi
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Front Biosci. 2007 May 1;12:4034-41. doi: 10.2741/2369.
Alternative splicing is an important and prevalent mechanism of gene regulation in higher eukaryotes. Nearly three quarters of human multi-exon genes are alternatively spliced. There is great interest in discovering alternative splicing events in the transcriptome of cancer cells, and in understanding how alternative splicing contributes to tumorigenesis. In this article, I will review recent advances in global analyses of pre-mRNA alternative splicing, and the applications of these genomic technologies to studies of alternative splicing in human cancers.
可变剪接是高等真核生物中一种重要且普遍的基因调控机制。近四分之三的人类多外显子基因会发生可变剪接。人们对在癌细胞转录组中发现可变剪接事件，以及了解可变剪接如何促进肿瘤发生非常感兴趣。在本文中，我将综述前体mRNA可变剪接全局分析的最新进展，以及这些基因组技术在人类癌症可变剪接研究中的应用。
