Ishizaka Nobukazu, Ishizaka Yuko, Toda Ei-Ichi, Nagai Ryozo, Yamakado Minoru
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Toyko, Japan.
J Atheroscler Thromb. 2007 Apr;14(2):72-7. doi: 10.5551/jat.14.72.
We have investigated whether metabolic syndrome is a risk factor for carotid atherosclerosis also in normotensive or prehypertensive individuals.
We analyzed the data from 851 subjects who had a blood pressure of less than 140/90 mmHg and were not taking antihypertensive medication. Metabolic syndrome was defined according to three different criteria: Japan criteria (Japan-MetS); those of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel III (ATP III) (NCEP-MetS); and modified NCEP-ATP III criteria in which body mass index was used as a surrogate for waist circumference (modified NCEP-MetS).
Japan-MetS, NCEP-MetS, and modified NCEP-MetS were found, respectively, in 1%, 4%, and 4%, of women, and in 10%, 5%, and 9%, of men. After the adjustment for gender and age, the association between MetS and carotid atherosclerosis did not reach statistical significance.
Although the number of enrolled subjects was relatively small, these data may further support the importance of controlling blood pressure within the optimal range for the purpose of preventing atherosclerosis in individuals with metabolic syndrome.
我们研究了代谢综合征是否也是血压正常或血压前期个体发生颈动脉粥样硬化的危险因素。
我们分析了851名血压低于140/90 mmHg且未服用抗高血压药物的受试者的数据。代谢综合征根据三种不同标准定义：日本标准（日本代谢综合征）；美国国家胆固醇教育计划（NCEP）成人治疗小组第三次报告（ATP III）的标准（NCEP代谢综合征）；以及使用体重指数替代腰围的改良NCEP-ATP III标准（改良NCEP代谢综合征）。
在女性中，分别有1%、4%和4%的人符合日本代谢综合征、NCEP代谢综合征和改良NCEP代谢综合征标准；在男性中，这一比例分别为10%、5%和9%。在对性别和年龄进行校正后，代谢综合征与颈动脉粥样硬化之间的关联未达到统计学显著性。
尽管纳入的受试者数量相对较少，但这些数据可能进一步支持将血压控制在最佳范围内对于预防代谢综合征个体发生动脉粥样硬化的重要性。
