Division of Endocrinology, Department of Internal Medicine, Cardinal Tien Hospital, Xindian 231, Taiwan.
Diabetes Res Clin Pract. 2009 Sep;85(3):335-41. doi: 10.1016/j.diabres.2009.06.020. Epub 2009 Jul 16.
We conducted this study to compare the relationships between subclinical atherosclerosis and metabolic syndrome (MS) defined by four definitions in Chinese subjects.
In 2006-2007, we enrolled 140 Chinese subjects without reported diabetes in this study. Anthropometric, biochemical profile, and carotid intima-media thickness (IMT) were measured. MS was defined by International Diabetes Federation (IDF), American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI), National Cholesterol Education Program Adult Treatment Panal III (NCEP-ATP III), and World Health Organization (WHO) criteria.
Subjects with MS defined by IDF and AHA/NHLBI criteria had significantly higher carotid IMT, controlling for age, gender, smoking, and serum LDL-C (MS by IDF, partial r=0.225, p=0.008; AHA/NHLBI, partial r=0.176, p=0.04). The association between carotid IMT and MS defined by NCEP-ATP III or WHO criteria was not significant. Subjects with more components of MS defined by IDF, AHA/NHLBI, or NCEP-ATP III criteria correlated to higher carotid IMT in adjusted models (p-values for trend, MS by IDF, 0.011; AHA/NHLBI, 0.011; NCEP-ATPIII, 0.01; WHO, 0.113).
MS definitions by IDF and AHA/NHLBI criteria are the best among four definitions in detecting subclinical atherosclerosis in non-diabetic Chinese subjects; whereas MS defined by WHO criteria is the worst.
本研究旨在比较四种定义的代谢综合征（MS）与亚临床动脉粥样硬化在中国人群中的关系。
2006-2007 年，我们纳入了本研究中无糖尿病报告的 140 名中国受试者。测量了人体测量学、生化指标和颈动脉内膜中层厚度（IMT）。MS 按照国际糖尿病联盟（IDF）、美国心脏协会和美国国立心肺血液研究所（AHA/NHLBI）、美国国家胆固醇教育计划成人治疗专家组第三版（NCEP-ATP III）和世界卫生组织（WHO）标准进行定义。
按照 IDF 和 AHA/NHLBI 标准定义的 MS 受试者颈动脉 IMT 显著更高，校正年龄、性别、吸烟和血清 LDL-C 后（IDF，偏相关系数 r=0.225，p=0.008；AHA/NHLBI，偏相关系数 r=0.176，p=0.04）。NCEP-ATP III 或 WHO 标准定义的颈动脉 IMT 与 MS 之间的关联不显著。校正模型中，按照 IDF、AHA/NHLBI 或 NCEP-ATP III 标准定义的 MS 具有更多组分的受试者与颈动脉 IMT 呈正相关（趋势检验 p 值，IDF，0.011；AHA/NHLBI，0.011；NCEP-ATPIII，0.01；WHO，0.113）。
在非糖尿病中国人群中，IDF 和 AHA/NHLBI 标准定义的 MS 是四种定义中检测亚临床动脉粥样硬化的最佳方法；而 WHO 标准定义的 MS 最差。
