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[睡眠呼吸暂停低通气综合征。概念、诊断与药物治疗]

[Sleep apnea-hypopnea syndrome. Concept, diagnosis and medical treatment].

作者信息

Eguía V M, Cascante J A

机构信息

Servicio de Neumología, Hospital Virgen del Camino, Pamplona.

出版信息

An Sist Sanit Navar. 2007;30 Suppl 1:53-74.

PMID:17486147
Abstract

The sleep apnea-hypopnea syndrome (SAHS) is characterised by daytime sleepiness, cardiorespiratory and cognitive disorders, secondary to repeated episodes of obstruction of the upper airway during sleep. This disease is highly prevalent in the general population and has damaging effects on the cardiovascular system; it increases the incidence of traffic accidents due to excessive somnolence, reduces the quality of life and is associated with an excess of mortality. It usually affects obese patients and the most important symptoms are snoring and repeated respiratory pauses. With each apnea and/or hypopnea there is a fall in saturation that alters the nocturnal average and ends up causing serious cardiovascular problems in the medium to long term. The destructuring of the architecture of sleep leads to daytime sleepiness that can interfere in social and working life. Diagnosis is carried out by means of polysomnography or respiratory poligraphy, an abbreviated method that is valid for 75% of cases. The most efficient medical treatment is the application of positive pressure to the airway (Continuous positive airway pressure - CPAP) that has scarce and light secondary effects and is in general well-tolerated. Once adapted, the patient must carry out an adjustment of the pressure through polysomnography and with the autoCPAP, which can vary pressure until the respiratory events are corrected. Primary care has an essential role to play in suspicion of the clinical symptoms, the correct utilisation of the referral criteria and the control of patients receiving treatment once adapted.

摘要

睡眠呼吸暂停低通气综合征(SAHS)的特征是白天嗜睡、心肺和认知障碍,继发于睡眠期间上呼吸道反复阻塞发作。这种疾病在普通人群中高度流行,对心血管系统有损害作用;因过度嗜睡增加交通事故发生率,降低生活质量,并与死亡率过高相关。它通常影响肥胖患者,最重要的症状是打鼾和反复呼吸暂停。每次呼吸暂停和/或低通气都会导致血氧饱和度下降,改变夜间平均值,并最终在中长期引发严重的心血管问题。睡眠结构的破坏导致白天嗜睡,可能干扰社交和工作生活。诊断通过多导睡眠图或呼吸描记法进行,后者是一种简化方法,对75%的病例有效。最有效的药物治疗是对气道施加正压(持续气道正压通气 - CPAP),其副作用少且轻微,总体耐受性良好。适应后,患者必须通过多导睡眠图和自动CPAP进行压力调整,自动CPAP可改变压力直至呼吸事件得到纠正。初级保健在怀疑临床症状、正确运用转诊标准以及对适应治疗后的患者进行控制方面起着至关重要的作用。

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