Kudo Takashi
Biomedical Imaging Research Center, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui, 910-1193, Japan.
Eur J Nucl Med Mol Imaging. 2007 Jun;34 Suppl 1:S49-61. doi: 10.1007/s00259-007-0440-3. Epub 2007 May 5.
There is growing evidence that myocardial metabolism plays a key role not only in ischaemic heart disease but also in a variety of diseases which involve myocardium globally, such as heart failure and diabetes mellitus. Understanding myocardial metabolism in such diseases helps to elucidate the pathophysiology and assists in making therapeutic decisions.
As well as providing information on regional changes, PET can deliver quantitative information about both regional and global changes in metabolism. This capability of quantitative measurement is one of the major advantages of PET along with physiological positron tracers, especially relevant in evaluating diseases which involve the whole myocardium.
This review discusses major PET tracers for metabolic imaging and their clinical applications and contributions to research regarding ischaemic heart disease and other diseases such as heart failure and diabetic heart disease. Future applications of positron metabolic tracers for the detection of vulnerable plaque are also highlighted briefly.
越来越多的证据表明，心肌代谢不仅在缺血性心脏病中起关键作用，而且在全球范围内涉及心肌的多种疾病中也起关键作用，如心力衰竭和糖尿病。了解此类疾病中的心肌代谢有助于阐明病理生理学，并有助于做出治疗决策。
除了提供有关区域变化的信息外，正电子发射断层扫描（PET）还可以提供有关代谢区域和整体变化的定量信息。这种定量测量能力是PET与生理性正电子示踪剂的主要优势之一，在评估累及整个心肌的疾病时尤为重要。
本综述讨论了用于代谢成像的主要PET示踪剂及其临床应用，以及它们对缺血性心脏病和其他疾病（如心力衰竭和糖尿病性心脏病）研究的贡献。还简要强调了正电子代谢示踪剂在检测易损斑块方面的未来应用。
