Sariguney Yakup, Demir Yucel Hakki, Yavuzer Reha, Elmas Cigdem, Atabay Kenan
Department of Plastic Reconstructive and Aesthetic Surgery, Gazi University Faculty of Medicine, Besevler, Ankara 06500, Turkey.
Aesthetic Plast Surg. 2007 Nov-Dec;31(6):692-6. doi: 10.1007/s00266-006-0008-9.
Soft tissue augmentation with autogenous tissue has been used to correct various defects during aesthetic facial contouring and reconstructive procedures. Although dermal grafts have longer survival rates, fat grafts always have been more popular because of the simple harvesting and grafting methods used. The authors aimed to use existing scar tissue as an injectable graft and to compare its effectiveness as a soft tissue filler substance with that of dermal grafts. In this study, scar tissue was created on 24 male Wistar rats. The created scar and normal healthy skin were removed from the rat dorsal scapular donor site. After depithelialization, the harvested tissues were minced until they were thin enough to pass through a 16-gauge needle. The grafts then were injected into the recipient site between the abdominal muscles. Volumetric analyses and histologic evaluation of the grafts were performed 1, 3, and 5 months after transplantation. The first month after the injection, the amount of remaining dermis graft was more than the scar graft, and this difference was statistically significant. However, at the end of months 3 and 5, there was no marked difference between the groups. The remaining volume of injected scar tissue graft was comparable with that of the dermis graft. The scar grafts were composed mainly of dense connective tissue during all the evaluation periods. In this study, scar tissue provided results comparable with those of dermal grafts up to 5 months when used as a soft tissue filler. It seems that neovascularization of the scar graft may be inadequate for maintenance of graft viability, as compared with dermis grafts. On the other hand, the scar graft formed fibrous tissue, which may be responsible for providing adequate volume as a filler. This may have clinical implications for the patient who needs both scar revision and soft tissue augmentation procedures simultaneously.
自体组织软组织填充已被用于在面部美学轮廓塑造和重建手术中纠正各种缺陷。尽管真皮移植的存活率更高，但由于脂肪移植的采集和移植方法简单，一直更受欢迎。作者旨在将现有的瘢痕组织用作可注射移植材料，并将其作为软组织填充物质的有效性与真皮移植进行比较。在本研究中，在24只雄性Wistar大鼠身上制造瘢痕组织。从大鼠背肩胛供区切除形成的瘢痕和正常健康皮肤。去上皮后，将收获的组织切碎，直到其薄到足以通过16号针头。然后将移植物注射到腹肌之间的受体部位。在移植后1、3和5个月对移植物进行体积分析和组织学评估。注射后的第一个月，剩余的真皮移植物量多于瘢痕移植物，且这种差异具有统计学意义。然而，在第3个月和第5个月末，两组之间没有明显差异。注射的瘢痕组织移植物的剩余体积与真皮移植物相当。在所有评估期内，瘢痕移植物主要由致密结缔组织组成。在本研究中，瘢痕组织用作软组织填充材料时，在长达5个月的时间内提供了与真皮移植物相当的结果。与真皮移植物相比，瘢痕移植物的新生血管形成似乎不足以维持移植物的活力。另一方面，瘢痕移植物形成了纤维组织，这可能是其作为填充材料提供足够体积的原因。这可能对同时需要瘢痕修复和软组织填充手术的患者具有临床意义。
