Department of Plastic and Reconstructive Surgery, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Aesthetic Plast Surg. 2011 Oct;35(5):738-44. doi: 10.1007/s00266-011-9679-y. Epub 2011 Apr 1.
Autogenous fat grafting is widely used for the correction of soft tissue contour deformity. However, the high absorption rate results in the need for overcorrection, and graft longevity is unpredictable. The authors hypothesized that epidermal growth factor (EGF), a potent stimulator of neovascularization, would improve fat graft survival. The experiment used two groups of New Zealand White Rabbit ear. Inguinal fat was harvested and injected with EGF or saline (n = 24, each group). The 48 cases of fat grafting were managed for observation of volume and morphologic change. The fat was harvested 3 months after the autogenous graft. The survival rate and the degree of neovascularization were measured. The grafts in the EGF group had a significantly higher survival rate than those in the control group. Histologic examination of the grafts demonstrated an increase in neovascularization and maintenance of fat cell morphology. These findings show that EGF can enhance fat graft survival and degree of neovascularization. Further well-controlled studies are required before EGF is used for clinical purposes.
自体脂肪移植被广泛用于纠正软组织轮廓畸形。然而，由于吸收率高，需要过度矫正，并且移植物的持久性不可预测。作者假设表皮生长因子（EGF），一种强有力的新生血管刺激剂，将改善脂肪移植物的存活。该实验使用了两组新西兰大白兔耳朵。腹股沟脂肪被采集并注射 EGF 或生理盐水（每组 n=24）。对 48 例脂肪移植病例进行了体积和形态变化的观察。在自体移植物 3 个月后采集脂肪。测量了存活率和新生血管化程度。EGF 组的移植物存活率明显高于对照组。对移植物的组织学检查显示新生血管化增加和脂肪细胞形态的维持。这些发现表明 EGF 可以提高脂肪移植物的存活率和新生血管化程度。在 EGF 用于临床之前，还需要进行更多的对照良好的研究。
