Pie M R
Universidade Federal do Paranà, Departamento de Zoologia, Curitiba, PR 81531, Brazil.
Genetika. 2007 Mar;43(3):427-9.
It has been recently suggested that the C-value paradox, the lack of an obvious association between organismal complexity and genome size, can result simply from biases in insertion and deletion rates--the DNA loss hypothesis. This hypothesis has been heavily criticized, particularly because its evidence, a negative relationship between genome size and DNA loss rate, is based on a highly selective use of the available data. In this study it is show that even the even the most favorable interpretation of the data favoring the DNA loss hypothesis is largely an artifact of phylogenetic nonindependence, supporting the assertion made by other authors that the mechanisms underlying genome size evolution might be more complex than envisioned by the DNA loss hypothesis.
最近有人提出，C值悖论，即生物体复杂性与基因组大小之间缺乏明显关联，可能仅仅是由于插入和缺失率的偏差——即DNA丢失假说。这一假说受到了严厉批评，特别是因为其证据，即基因组大小与DNA丢失率之间的负相关关系，是基于对现有数据的高度选择性使用。在本研究中表明，即使是对支持DNA丢失假说的数据最有利的解释，在很大程度上也是系统发育非独立性的产物，这支持了其他作者的观点，即基因组大小进化的潜在机制可能比DNA丢失假说所设想的更为复杂。
