Tupin Emmanuel, Kinjo Yuki, Kronenberg Mitchell
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA.
Nat Rev Microbiol. 2007 Jun;5(6):405-17. doi: 10.1038/nrmicro1657. Epub 2007 May 8.
Natural killer T (NKT) cells combine features of the innate and adaptive immune systems. Recently, it has become evident that these T cells have crucial roles in the response to infectious agents. The antigen receptor expressed by NKT cells directly recognizes unusual glycolipids that are part of the membrane of certain Gram-negative bacteria and spirochetes. Moreover, even in the absence of microbial glycolipid antigens, these T cells respond to innate cytokines produced by dendritic cells that have been activated by microbes. This indirect sensing of infection, by responding to cytokines from activated dendritic cells, allows NKT cells to react to a broad range of infectious agents.
自然杀伤T（NKT）细胞兼具先天性和适应性免疫系统的特征。最近，有一点变得很明显，即这些T细胞在对感染因子的应答中发挥着关键作用。NKT细胞表达的抗原受体能直接识别某些革兰氏阴性菌和螺旋体细胞膜上的特殊糖脂。此外，即使在没有微生物糖脂抗原的情况下，这些T细胞也会对被微生物激活的树突状细胞产生的先天性细胞因子作出反应。通过对活化树突状细胞产生的细胞因子作出反应，这种对感染的间接感知使NKT细胞能够对多种感染因子作出反应。
