暴发性1型糖尿病的发病机制。
Pathogenesis of fulminant type 1 diabetes.
作者信息
Imagawa Akihisa, Hanafusa Toshiaki
机构信息
First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan.
出版信息
Rev Diabet Stud. 2006 Winter;3(4):169-77. doi: 10.1900/RDS.2006.3.169. Epub 2007 Feb 10.
Abstract
Fulminant type 1 diabetes is a new subtype of type 1 diabetes. The term was established in 2000. It is a syndrome characterized by a markedly rapid and almost complete destruction of pancreatic beta-cells. Several lines of evidence suggest that both genetic factors, such as human leukocyte antigen (HLA), and environmental factors, such as viral infection, contribute to the development of this disease. It is also suggested that autoimmune processes contribute less critically to fulminant type 1 diabetes than to classic type 1A diabetes. Based on the findings made to date, both viral infection and the subsequent immune reaction in genetically susceptible individuals cause beta-cell destruction and lead to fulminant type 1 diabetes.
摘要
暴发性1型糖尿病是1型糖尿病的一种新亚型。该术语于2000年确立。它是一种以胰腺β细胞明显快速且几乎完全破坏为特征的综合征。多项证据表明，诸如人类白细胞抗原（HLA）等遗传因素以及诸如病毒感染等环境因素都促成了这种疾病的发生。也有观点认为，自身免疫过程对暴发性1型糖尿病的作用不如对经典1A型糖尿病那样关键。基于迄今所取得的研究结果，病毒感染以及遗传易感个体随后发生的免疫反应会导致β细胞破坏，进而引发暴发性1型糖尿病。
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