与典型 1 型糖尿病相比暴发性 1 型糖尿病的临床特征：来自广东 T1DM 转化医学研究的为期 1 年的随访研究。
Clinical Characteristics of Fulminant Type 1 Diabetes Compared with Typical Type 1 Diabetes: One-Year Follow-Up Study from the Guangdong T1DM Translational Medicine Study.
机构信息
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou 510630, China.
Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences of Medicine, University of Science and Technology of China, Hefei 230026, China.
出版信息
J Diabetes Res. 2020 Feb 19;2020:8726268. doi: 10.1155/2020/8726268. eCollection 2020.
BACKGROUND
Fulminant type l diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus (T1DM) with abrupt onset, but data on its progression was limited. This study was aimed at exploring the clinical features through one-year follow-up. . Patients with T1DM finishing at least one-year follow-up from June 2011 to July 2018 were enrolled from Guangdong Type 1 Diabetes Translational Medicine Study. Patients who fulfilled the respective criteria were categorized as an FT1DM group and a typical T1DM group (TT1DM). The 1 : 4 propensity score matching based on onset age, duration, and gender was performed between the FT1DM and TT1DM groups. Characteristics at the onset and after one-year follow-up were compared between the two groups.
RESULTS
A total of 53 patients with FT1DM and 212 matched patients with TT1DM were included. At the onset, there was a shorter duration of symptomatic period before diagnosis observed in the FT1DM group than in the TT1DM group (2 [1, 7] vs. 30 [10, 60] days, < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis ( < 0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis (.
CONCLUSION
Patients with FT1DM had more severe metabolic derangement and deficiency of insulin secretion than patients with TT1DM at the onset, but glycaemic and metabolic control was not worse than that in TT1DM.
背景
暴发性 1 型糖尿病（FT1DM）是 1 型糖尿病（T1DM）的一个亚型，具有突然发作的特点，但关于其进展的数据有限。本研究旨在通过为期一年的随访来探索其临床特征。
方法
自 2011 年 6 月至 2018 年 7 月，广东 1 型糖尿病转化医学研究（Guangdong Type 1 Diabetes Translational Medicine Study）中纳入了至少完成一年随访的 T1DM 患者。符合各自标准的患者分为 FT1DM 组和典型 T1DM 组（TT1DM）。根据发病年龄、病程和性别，对 FT1DM 组和 TT1DM 组进行了 1：4 的倾向评分匹配。比较两组患者发病时和随访一年后的特征。
结果
共纳入 53 例 FT1DM 患者和 212 例匹配的 TT1DM 患者。FT1DM 组患者诊断前症状期持续时间短于 TT1DM 组（2[1,7]vs.30[10,60]天，<0.001）。FT1DM 患者的血糖水平更高，糖尿病酮症酸中毒的比例更高（<0.001）。
结论
FT1DM 患者发病时的代谢紊乱和胰岛素分泌不足比 TT1DM 患者更严重，但血糖和代谢控制并不比 TT1DM 差。
Zotero 插件