Miyazawa Mitsuo, Sakata Kazuki
Faculty of Science and Engineering, Department of Applied Chemistry, Kinki University, Kowakae, Osaka 577-8502, Japan.
Nat Prod Res. 2007 May;21(5):455-60. doi: 10.1080/14786410601083894.
The biotransformation of terpenoids using the plant pathogenic fungus as a biocatalyst to produce useful novel organic compounds was investigated. The biotransformation of sesquiterpen alcohol, (+)-cycloisolongifolol (1) was investigated using plant pathogenic fungus Glomerella cingulata as a biocatalyst. Compound 1 gave one major metabolic product and a number of minor metabolic products. Major product was dehydration at the C-8 position to (+)-dehydrocycloisolongifolene (2). The structure of the product was determined by their spectroscopic data. Glomerella cingulata gave dehydration in the specifically and over 70% conversion.
研究了利用植物致病真菌作为生物催化剂对萜类化合物进行生物转化以生产有用的新型有机化合物。使用植物致病真菌胶孢炭疽菌作为生物催化剂，研究了倍半萜醇（+）-环异长叶烯（1）的生物转化。化合物1产生了一种主要代谢产物和许多次要代谢产物。主要产物是在C-8位脱水生成（+）-脱氢环异长叶烯（2）。通过光谱数据确定了产物的结构。胶孢炭疽菌能特异性地进行脱水反应，转化率超过70%。
