Dick Frederic, Saygin Ayse Pinar, Galati Gaspare, Pitzalis Sabrina, Bentrovato Simone, D'Amico Simona, Wilson Stephen, Bates Elizabeth, Pizzamiglio Luigi
Birkbeck College, London, UK.
J Cogn Neurosci. 2007 May;19(5):799-816. doi: 10.1162/jocn.2007.19.5.799.
We used functional magnetic resonance imaging (fMRI) in conjunction with a voxel-based approach to lesion symptom mapping to quantitatively evaluate the similarities and differences between brain areas involved in language and environmental sound comprehension. In general, we found that language and environmental sounds recruit highly overlapping cortical regions, with cross-domain differences being graded rather than absolute. Within language-based regions of interest, we found that in the left hemisphere, language and environmental sound stimuli evoked very similar volumes of activation, whereas in the right hemisphere, there was greater activation for environmental sound stimuli. Finally, lesion symptom maps of aphasic patients based on environmental sounds or linguistic deficits [Saygin, A. P., Dick, F., Wilson, S. W., Dronkers, N. F., & Bates, E. Shared neural resources for processing language and environmental sounds: Evidence from aphasia. Brain, 126, 928-945, 2003] were generally predictive of the extent of blood oxygenation level dependent fMRI activation across these regions for sounds and linguistic stimuli in young healthy subjects.
我们使用功能磁共振成像（fMRI）并结合基于体素的病变症状映射方法，来定量评估参与语言和环境声音理解的脑区之间的异同。总体而言，我们发现语言和环境声音会激活高度重叠的皮质区域，跨领域差异是渐变的而非绝对的。在基于语言的感兴趣区域内，我们发现，在左半球，语言和环境声音刺激诱发的激活量非常相似，而在右半球，环境声音刺激引发的激活更强。最后，基于环境声音或语言缺陷的失语症患者病变症状映射[Saygin, A. P., Dick, F., Wilson, S. W., Dronkers, N. F., & Bates, E. 处理语言和环境声音的共享神经资源：来自失语症的证据。《大脑》，126卷，928 - 945页，2003年]通常能够预测年轻健康受试者在这些区域对声音和语言刺激的血氧水平依赖性功能磁共振成像激活程度。
