Rhodes John M, Simons Michael
Angiogenesis Research Center, Section of Cardiology, Departments of Medicine and Pharmacology & Toxicology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.
J Cell Mol Med. 2007 Mar-Apr;11(2):176-205. doi: 10.1111/j.1582-4934.2007.00031.x.
The extracellular matrix plays a number of important roles, among them providing structural support and information to cellular structures such as blood vessels imbedded within it. As more complex organisms have evolved, the matrix ability to direct signalling towards the vasculature and remodel in response to signalling from the vasculature has assumed progressively greater importance. This review will focus on the molecules of the extracellular matrix, specifically relating to vessel formation and their ability to signal to the surrounding cells to initiate or terminate processes involved in blood vessel formation.
细胞外基质发挥着许多重要作用，其中包括为嵌入其中的血管等细胞结构提供结构支持和信息。随着更复杂的生物体不断进化，基质向脉管系统发出信号以及响应脉管系统发出的信号进行重塑的能力变得越来越重要。本综述将聚焦于细胞外基质的分子，特别是与血管形成相关的分子以及它们向周围细胞发出信号以启动或终止血管形成相关过程的能力。
