Ditschkowski Markus, Elmaagacli Ahmet H, Trenschel Rudolf, Peceny Rudolf, Koldehoff Michael, Schulte Claudia, Beelen Dietrich W
Department of bone marrow transplantation, University Hospital of Essen, Essen, Germany.
Haematologica. 2007 Apr;92(4):558-61. doi: 10.3324/haematol.10710.
Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT). In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant. No BOOP or BO was diagnosed following T-cell depletion (p<0.05). Chronic GVHD was ascertained in all BOOP patients and appeared significantly (p<0,001) more frequent in the conventional transplant group. The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP.
闭塞性细支气管炎（BO）和闭塞性细支气管炎伴机化性肺炎（BOOP）是异基因造血干细胞移植（HSCT）后发生的迟发性非感染性肺部并发症（LONIPCs）。在本研究中，197例传统制备的干细胞受者中有10例在365天后发生BOOP，6例患者在移植后333天发生BO。T细胞清除后未诊断出BOOP或BO（p<0.05）。所有BOOP患者均确诊为慢性移植物抗宿主病（GVHD），且在传统移植组中显著更常见（p<0.001）。数据证实了T细胞活性、慢性GVHD、BO和BOOP之间存在密切关联，并指出T淋巴细胞在BOOP发病机制中的作用。
