血红蛋白E杂合子以及血红蛋白E和α地中海贫血双重杂合子婴儿中βE和γ珠蛋白基因的表达
Expression of betaE and gamma-globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and alpha-thalassemia.
作者信息
Winichagoon Pranee, Svasti Saovaros, Winichagoon Pattanee, Chitchumroonchokchai Chureeporn, Fucharoen Suthat
出版信息
Haematologica. 2007 May;92(5):702-3. doi: 10.3324/haematol.10930.
PMID:17488699
Abstract
This study described the expression of betaE-globin in newborns heterozygous for HbE. Despite the lower level of HbE, the pattern of betaE-globin gene expression was similar to betaA-globin because the increase in HbE and HbA reached the peak level at the same time. A delayed decline of HbF was observed.
摘要
本研究描述了HbE杂合子新生儿中βE-珠蛋白的表达情况。尽管HbE水平较低，但βE-珠蛋白基因的表达模式与βA-珠蛋白相似，因为HbE和HbA的增加在同一时间达到峰值水平。观察到HbF的下降延迟。
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