Berhe Nega, Halvorsen Bente L, Gundersen Thomas E, Myrvang Bjørn, Gundersen Svein G, Blomhoff Rune
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Am J Trop Med Hyg. 2007 May;76(5):943-9.
To study the relationship between micronutrient malnutrition and schistosomiasis mansoni, a cross-sectional study was undertaken involving 421 schoolchildren (mean age 12.6 years; 333 from schistosomiasis mansoni-endemic villages (Workemado and Sille) and 88 non-endemic controls from Sheno). Prevalence of schistosomiasis mansoni infection in Workemado and Sille was comparable (90.6% versus 95%, respectively), and prevalence of PPF in Workemado was significantly higher than in Sille (7.0% versus 0.6%, P < 0.001). Compared with non-endemic controls, serum retinol concentrations were significantly lower and hydroperoxides were significantly higher in subjects from schistosomiasis mansoni-endemic areas. Furthermore, serum alpha-tocopherol concentrations in subjects from an area with high prevalence of PPF were significantly reduced while the concentrations in subjects from an area with low prevalence of PPF were comparable to the levels found in non-endemic healthy controls. In conclusion, micronutrient malnutrition and oxidative stress are associated with Schistosoma mansoni infection and levels of schistosomal PPF.
为研究微量营养素营养不良与曼氏血吸虫病之间的关系，开展了一项横断面研究，涉及421名学童（平均年龄12.6岁；333名来自曼氏血吸虫病流行村庄（沃克马多和西勒），88名非流行对照来自谢诺）。沃克马多和西勒的曼氏血吸虫病感染率相当（分别为90.6%和95%），沃克马多的PPF患病率显著高于西勒（7.0%对0.6%，P<0.001）。与非流行对照相比，曼氏血吸虫病流行地区受试者的血清视黄醇浓度显著降低，氢过氧化物显著升高。此外，PPF高流行地区受试者的血清α-生育酚浓度显著降低，而PPF低流行地区受试者的血清α-生育酚浓度与非流行健康对照相当。总之，微量营养素营养不良和氧化应激与曼氏血吸虫感染及血吸虫性PPF水平有关。
