来自阿比西尼亚刺桐茎皮的异戊烯基黄酮类化合物。
Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.
作者信息
Cui Long, Ndinteh Derek Tantoh, Na MinKyun, Thuong Phuong Thien, Silike-Muruumu John, Njamen Dieudonné, Mbafor Joseph Tanyi, Fomum Zacharias Tanee, Ahn Jong Seog, Oh Won Keun
机构信息
Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Yuseong-gu, Daejeon 305-806, Korea.
出版信息
J Nat Prod. 2007 Jun;70(6):1039-42. doi: 10.1021/np060477+. Epub 2007 May 10.
Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 +/- 1.7 to 26.7 +/- 1.2 microM.
从阿比西尼亚刺桐的茎皮中分离出三种新的异戊烯基黄酮，即阿比西尼亚黄酮V、VI和VII（1-3），以及八种已知的黄酮（4-11）和两种查耳酮（12-13）。通过光谱和物理化学分析确定了它们的结构。除1和8外，所有分离物在体外试验中均强烈抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性，IC50值范围为14.2±1.7至26.7±1.2微摩尔。
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