Obakiro Samuel Baker, Kiprop Ambrose, Kigondu Elizabeth, K'Owino Isaac, Odero Mark Peter, Manyim Scolastica, Omara Timothy, Namukobe Jane, Owor Richard Oriko, Gavamukulya Yahaya, Bunalema Lydia
Department of Pharmacology and Therapeutics, Faculty of Health Sciences, Busitema University, P.O. Box 1460, Mbale, Uganda.
Department of Chemistry and Biochemistry, School of Sciences and Aerospace Studies, Moi University, P.O. Box 3900-30100, Eldoret, Kenya.
Evid Based Complement Alternat Med. 2021 Mar 3;2021:5513484. doi: 10.1155/2021/5513484. eCollection 2021.
Many studies have been undertaken on the medicinal values of Lam. ex DC. (Fabaceae). The details, however, are highly fragmented in different journals, libraries, and other publication media. This study was therefore conducted to provide a comprehensive report on its ethnobotany, ethnomedicinal uses, phytochemicals, and the available pharmacological evidence supporting its efficacy and safety in traditional medicine.
We collected data using a PROSPERO registered systematic review protocol on the ethnobotany, phytochemistry, and ethnopharmacology of from 132 reports that were retrieved from electronic databases. Documented local names, morphology, growth habit and habitat, ethnomedicinal and nonmedicinal uses, diseases treated, parts used, method of preparation and administration, extraction and chemical identity of isolated compounds, and efficacy and toxicity of extracts and isolated compounds were captured. Numerical data were summarized into means, percentages, and frequencies and presented as graphs and tables.
is harvested by traditional herbal medicine practitioners in East, Central, and South African communities to prepare herbal remedies for various human and livestock ailments. These include bacterial and fungal infections, tuberculosis, malaria, HIV/AIDS, diarrhea, cancer, meningitis, inflammatory diseases, urinary tract infections, wounds, diabetes mellitus, and skin and soft tissue injuries. Different extracts and phytochemicals from parts of have been scientifically proven to possess anti-inflammatory, antibacterial, antioxidant, antiplasmodial, antiproliferative, antifungal, antimycobacterial, antidiarrheal, anti-HIV 1, antidiabetic, and antiobesity activities. This versatile pharmacological activity is due to the abundant flavonoids, alkaloids, and terpenoids present in its different parts.
is an important ethnomedicinal plant in Africa harboring useful pharmacologically active phytochemicals against various diseases with significant efficacies and minimal toxicity to mammalian cells. Therefore, this plant should be conserved and its potential to provide novel molecules against diseases be explored further. Clinical trials that evaluate the efficacy and safety of extracts and isolated compounds from are recommended.
许多关于Lam. ex DC.（豆科）药用价值的研究已经开展。然而，细节在不同的期刊、图书馆和其他出版媒介中高度分散。因此，开展本研究以提供一份关于其民族植物学、民族药用用途、植物化学物质以及支持其在传统医学中的功效和安全性的现有药理学证据的综合报告。
我们使用PROSPERO注册的系统评价方案，从电子数据库检索的132份报告中收集关于Lam. ex DC.的民族植物学、植物化学和民族药理学的数据。记录了当地名称、形态、生长习性和栖息地、民族药用和非药用用途、治疗的疾病、使用的部位、制备和给药方法、分离化合物的提取和化学特性，以及提取物和分离化合物的功效和毒性。数值数据总结为均值、百分比和频率，并以图表形式呈现。
东非、中非和南非社区的传统草药从业者采集Lam. ex DC.来制备用于治疗各种人畜疾病的草药。这些疾病包括细菌和真菌感染、结核病、疟疾、艾滋病毒/艾滋病、腹泻、癌症、脑膜炎、炎症性疾病、尿路感染、伤口、糖尿病以及皮肤和软组织损伤。从Lam. ex DC.的不同部位提取的不同提取物和植物化学物质已被科学证明具有抗炎、抗菌、抗氧化、抗疟原虫、抗增殖、抗真菌、抗分枝杆菌、止泻、抗艾滋病毒1、抗糖尿病和抗肥胖活性。这种多样的药理活性归因于其不同部位中丰富的黄酮类化合物、生物碱和萜类化合物。
Lam. ex DC.是非洲一种重要的民族药用植物，含有对多种疾病有效的、对哺乳动物细胞毒性极小的具有药理活性的有用植物化学物质。因此，应该保护这种植物，并进一步探索其提供抗疾病新分子的潜力。建议开展评估Lam. ex DC.提取物和分离化合物的功效和安全性的临床试验。
