Luby Joan L, Stalets Melissa Meade, Belden Andy C
Washington University School of Medicine, Department of Psychiatry, St. Louis, Missouri 63108, USA.
J Child Adolesc Psychopharmacol. 2007 Apr;17(2):205-15. doi: 10.1089/cap.2007.0023.
Epidemiological data has shown that psychotropic medications are being prescribed to preschoolers at increasing rates. The diagnostic context and functional impairment of these preschoolers remains unknown. This investigation aimed to address these questions in a sample of preschoolers who were either without symptoms (healthy) or with mood and disruptive disorders by assessing them using a structured diagnostic interview and measure of impairment.
Preschoolers aged 3.0 to 5.11 without symptoms and those with symptoms of mood and disruptive disorders were recruited from primary care and daycare sites in the St. Louis area to participate in a psychiatric evaluation that included information about psychotropic prescriptions from community practitioners.
Seven percent of preschoolers (n = 19) out of a total sample of n = 267 were prescribed psychotropic medications. Fifty-two percent of preschoolers in the total sample met criteria for an Axis I psychiatric disorder. Presence of an Axis I disorder was significantly related to psychotropic prescription (p < 0.01). Among preschoolers who met criteria for an Axis I disorder 12% received psychotropics (Dx/Rx group). The Dx/Rx group was more impaired than those with a diagnosis who were not prescribed psychotropics (p < 0.001). Among preschoolers taking psychotropic medications, two failed to meet criteria for any Axis I disorder.
In this sample, most psychotropic medications were prescribed for impaired preschoolers with an Axis I diagnosis. These findings shed some light on the prescribing trends among mood and disruptive disordered preschoolers.
流行病学数据显示,精神类药物在学龄前儿童中的处方率正在上升。这些学龄前儿童的诊断背景和功能损害情况仍不明确。本研究旨在通过使用结构化诊断访谈和损害评估方法,对无症状(健康)或患有情绪及破坏性行为障碍的学龄前儿童样本进行调查,以解决这些问题。
从圣路易斯地区的初级保健机构和日托中心招募3.0至5.11岁无症状以及有情绪和破坏性行为障碍症状的学龄前儿童,参与包括社区医生开具的精神类药物处方信息的精神病学评估。
在总共267名学龄前儿童样本中,7%(n = 19)被开具了精神类药物。总样本中有52%的学龄前儿童符合轴I精神障碍标准。轴I障碍的存在与精神类药物处方显著相关(p < 0.01)。在符合轴I障碍标准的学龄前儿童中,12%接受了精神类药物治疗(诊断/处方组)。诊断/处方组比那些被诊断但未开具精神类药物的儿童功能损害更严重(p < 0.001)。在服用精神类药物的学龄前儿童中,有两名未符合任何轴I障碍标准。
在这个样本中,大多数精神类药物是开给患有轴I诊断且有功能损害的学龄前儿童。这些发现揭示了患有情绪及破坏性行为障碍的学龄前儿童的处方趋势。