Crew Mark D
Central Arkansas Veterans Healthcare System and Department of Microbiology & Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Xenotransplantation. 2007 May;14(3):198-207. doi: 10.1111/j.1399-3089.2007.00395.x.
Human NK cell-mediated graft rejection is likely to be one of several biological obstacles to routine pig-to-human xenotransplantation. Abrogating NK cell activation by either elimination of activating ligands on porcine cells or expression of molecules serving as ligands for NK cell inhibitory receptors, or both, could overcome this hurdle. HLA-E and -G exhibit very limited polymorphism and are ligands for NK cell inhibitory receptors. This review summarizes successes and limitations of their use in xenotransplantation as inferred from ex vivo analyses of NK cell activity, highlights potential effects they may have on T-cell responses, and considers prospects of preclinical trials and potential outcomes.
人类自然杀伤（NK）细胞介导的移植物排斥很可能是常规猪到人的异种移植面临的若干生物学障碍之一。通过消除猪细胞上的激活配体或表达作为NK细胞抑制性受体配体的分子，或两者兼而有之，来废除NK细胞的激活，可能会克服这一障碍。HLA-E和-HLA-G表现出非常有限的多态性，并且是NK细胞抑制性受体的配体。本综述总结了从NK细胞活性的体外分析推断出的它们在异种移植中使用的成功和局限性，强调了它们可能对T细胞反应产生的潜在影响，并考虑了临床前试验的前景和潜在结果。
