Newell E L, Mallipeddi R, Murdoch M E, Groves R, Black M M, Robson A
St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
Clin Exp Dermatol. 2007 Sep;32(5):509-12. doi: 10.1111/j.1365-2230.2007.02426.x. Epub 2007 May 8.
Cutaneous extravascular necrotizing granuloma, an unusual palisading dermal granuloma, was first described by Churg and Strauss in 1951 in association with the syndrome of allergic granulomatosis (Churg-Strauss syndrome), for which it was though to be pathognomonic. It has subsequently been described in association with a number of autoimmune and immunoreactive diseases, and is regarded as a cutaneous marker of systemic pathology. To our knowledge, only one patient has been reported with clinical features confined to the skin. We report a 46-year-old woman with recurrent cutaneous lesions over a 10-year period and the classic histopathological pattern, but no underlying systemic disease.
皮肤血管外坏死性肉芽肿是一种罕见的栅栏状真皮肉芽肿，1951年由丘格和施特劳斯首次描述，与变应性肉芽肿病综合征（丘格-施特劳斯综合征）相关，当时认为它具有诊断特异性。随后有报道称其与多种自身免疫性和免疫反应性疾病相关，并被视为系统性病变的皮肤标志物。据我们所知，仅有1例患者的临床特征局限于皮肤。我们报告1例46岁女性，在10年期间反复出现皮肤病变，具有典型的组织病理学模式，但无潜在的系统性疾病。
