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顺式解码器发现了组织特异性增强子之间共享的保守DNA序列群。

cis-Decoder discovers constellations of conserved DNA sequences shared among tissue-specific enhancers.

作者信息

Brody Thomas, Rasband Wayne, Baler Kevin, Kuzin Alexander, Kundu Mukta, Odenwald Ward F

机构信息

Neural Cell-Fate Determinants Section, NINDS, NIH, Bethesda, MD 20892, USA.

出版信息

Genome Biol. 2007;8(5):R75. doi: 10.1186/gb-2007-8-5-r75.

DOI:10.1186/gb-2007-8-5-r75
PMID:17490485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1929141/
Abstract

A systematic approach is described for analysis of evolutionarily conserved cis-regulatory DNA using cis-Decoder, a tool for discovery of conserved sequence elements that are shared between similarly regulated enhancers. Analysis of 2,086 conserved sequence blocks (CSBs), identified from 135 characterized enhancers, reveals most CSBs consist of shorter overlapping/adjacent elements that are either enhancer type-specific or common to enhancers with divergent regulatory behaviors. Our findings suggest that enhancers employ overlapping repertoires of highly conserved core elements.

摘要

本文描述了一种系统方法，用于使用cis-Decoder分析进化上保守的顺式调控DNA，cis-Decoder是一种用于发现相似调控增强子之间共享的保守序列元件的工具。对从135个已表征增强子中鉴定出的2086个保守序列块（CSB）进行分析，结果显示大多数CSB由较短的重叠/相邻元件组成，这些元件要么是增强子类型特异性的，要么是具有不同调控行为的增强子所共有的。我们的研究结果表明，增强子采用高度保守的核心元件的重叠组合。

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