Welch L, Kirshner H, Heath A, Gilliland R, Broyles S
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2647.
J Toxicol Clin Toxicol. 1991;29(4):435-45. doi: 10.3109/15563659109025739.
A 38 year-old laborer experienced solvent intoxication during each of two spray paintings of a dump truck and other heavy equipment in an enclosed, unventilated garage. The paint base consisted primarily of toluene and methyl ethyl ketone. Nausea, headaches, dizziness, respiratory difficulty and other symptoms began after exposures. Over the next several days he developed impaired concentration, memory loss and cerebellar signs including an intention tremor, gait ataxia and dysarthria. MRI of the brain and EGG early in the work-up were normal, although later MRIs demonstrated fluid collection over the left parietal area. Examination by a toxicologist and neurologist revealed likely toxic encephalopathy with dementia and cerebellar ataxia. Three formal neuropsychological assessments over 2 1/2 years quantified cognitive, motor and behavioral changes. Despite similar findings in chronic exposure to these solvents, lasting sequelae following acute exposure have not been widely reported.
一名38岁的工人在一个封闭、不通风的车库里对一辆自卸卡车和其他重型设备进行两次喷漆作业时，均出现了溶剂中毒情况。油漆底料主要由甲苯和甲乙酮组成。接触后出现了恶心、头痛、头晕、呼吸困难及其他症状。在接下来的几天里，他出现了注意力不集中、记忆力减退以及小脑体征，包括意向性震颤、步态共济失调和构音障碍。检查初期的脑部MRI和脑电图结果正常，不过后来的MRI显示左顶叶区域有积液。毒理学家和神经学家的检查表明可能患有中毒性脑病，伴有痴呆和小脑共济失调。在2年半的时间里进行了三次正式的神经心理学评估，对认知、运动和行为变化进行了量化。尽管长期接触这些溶剂会有类似发现，但急性接触后的持久性后遗症尚未得到广泛报道。
